He is passionate about pursuing fundamental questions in ribonucleic acid (RNA) biology and believes such knowledge can be exploited to create powerful RNA-based biotechnology and therapeutics. He has made highly significant contributions to the RNA interference (RNAi) field, including the discovery of the subunit structure of RNA polymerase V (2009) and the invention of the prokaryotic small interfering RNA (siRNA) technology, the world's first cell-based method for siRNA production (2013). Currently, his research team is studying antisense RNA biology, RNAi applications and delivery, and the infection mechanisms of Clostridium difficile and Zika virus. At Duke Kunshan, his teaching interests include microbiology, genetics, cell biology and molecular biology.
His research has been published in mBio, Science Advances, Biotechnology and Bioengineering, BBRC, among others, and was supported by grants from the National Natural Science Foundation of China; the Science, Technology and the Innovation Commission of Shenzhen; and three major funding schemes – ITF, HMRF and RGC – in Hong Kong. He is also the founder of Xiaomo Biotech at Hong Kong Science Park.
Huang has a B.Sc. from the College of Biological Sciences, China Agricultural University, Beijing, and a Ph.D. from the University of East Anglia, U.K. Between 2009 and 2014, he completed his postdoctoral training with Judy Lieberman at Boston Children's Hospital and Harvard Medical School. Before joining Duke Kunshan, he was an associate professor at the Department of Biomedical Sciences, City University of Hong Kong.
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