Dr. Kappes’s research investigates the molecular mechanisms at the intersection of chromatin biology, epigenetics, and tumor development. A central focus is the DEK oncoprotein, a unique chromatin architectural factor. His lab employs multidisciplinary approaches to define how DEK regulates chromatin structure and integrity, with specific interests in its roles during DNA damage processes, ribosome biogenesis, and the maintenance of heterochromatin. Understanding these fundamental processes provides insights into how dysregulation of DEK contributes to cancer progression. His work has resulted in over 40 peer-reviewed publications in journals such as Genes & Development, PNAS, and Nature Communications, supported by grants from the German Research Council (DFG), the Arthritis Foundation, and internal university awards.

Dr. Kappes is dedicated to integrative science education and mentors students across all levels. His teaching interests include Molecular Biology, Cell Biology, Biochemistry, and Epigenetics. He emphasizes connecting core principles with current research, particularly in chromatin and cancer biology, to prepare students for careers in research and medicine. He has extensive experience supervising undergraduate and graduate thesis projects, guiding numerous PhD, Master’s, and undergraduate students to successful completion of their degrees.

Committed to teaching excellence, Dr. Kappes has held significant administrative roles focused on enhancing pedagogy and curriculum. Prior to joining Duke Kunshan, he served as the inaugural Associate Dean for Learning and Teaching in the School of Science at Xi’an Jiaotong-Liverpool University (XJTLU), where he also chaired the Departmental Teaching & Learning Committee. In these capacities, he led major initiatives including curriculum reviews, accreditation processes, and the development of programs to promote teaching excellence.

He received his Diplom (combined BSc/MRes) in Molecular Biology and his Ph.D. from the University of Konstanz, Germany. He conducted postdoctoral research at the University of Konstanz and at the University of Michigan Medical Center, and established his independent research group at RWTH Aachen University, Germany before moving to a senior faculty position at XJTLU and subsequently to Duke Kunshan University in 2022.